Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

STAT1

External links	Primary Information
MGI:103063 ENSMUSG00000026104	Gene Symbol	Stat1
	Affected Anatomical Systems	cardiovascular system phenotype,cellular phenotype,digestive/alimentary phenotype,growth/size phenotype,hematopoietic system phenotype,homeostasis/metabolism phenotype,immune system phenotype,lethality-postnatal,life span-post-weaning/aging,limbs/digits/tail phenotype,liver/biliary system phenotype,muscle phenotype,nervous system phenotype,skeleton phenotype,tumorigenesis,vision/eye phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:3611892 Stat1fae Chemically induced (ENU) face MGI:3619019 Stat1m1Btlr Chemically induced (ENU) mutation 1, Bruce Beutler 16688530 MGI:3785244 Stat1m2Btlr Chemically induced (ENU) mutation 2, Bruce Beutler MGI:1930947 Stat1tm1Dlv Targeted (knock-out) targeted mutation 1, David E Levy 8608598 MGI:1861949 Stat1tm1Rds Targeted (knock-out) targeted mutation 1, Robert D Schreiber 8608597 MGI:3774319 Stat1tm1Tdec Targeted (knock-in) targeted mutation 1, Thomas Decker 14670297
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Increased Susceptibility To Bacterial Infection Stat1tm1Rds>/Stat1 either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) 8608597 Increased Susceptibility To Viral Infection Stat1tm1Rds>/Stat1 either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) 8608597 Abnormal Cell Physiology Stat1tm1Rds>/Stat1 either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) 8608597 Decreased Body Size Stat1tm1Dlv>/Stat1 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1) 8608598 Abnormal Intestine Morphology Stat1tm1Dlv>/Stat1 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1) 8608598 Abnormal Leukocyte Physiology Stat1tm1Dlv>/Stat1 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1) 8608598 Increased Susceptibility To Viral Infection Stat1tm1Dlv>/Stat1 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1) 8608598 Multifocal Hepatic Necrosis Stat1tm1Dlv>/Stat1 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1) 8608598 Lethality At Weaning Stat1tm1Dlv>/Stat1 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1) 8608598 Abnormal Cornea Morphology Stat1tm1Rds>/Stat1 involves: 129/Sv 10865997 Increased Susceptibility To Viral Infection Stat1tm1Rds>/Stat1 involves: 129/Sv 11390995 Abnormal Cell Cycle Stat1tm1Rds>/Stat1 involves: 129/Sv 14617019 Decreased Apoptosis Stat1tm1Rds>/Stat1 involves: 129/Sv 10865997 Abnormal Common Myeloid Progenitor Cell Morphology Stat1tm1Rds>/Stat1 involves: 129/Sv 14617019 Increased Susceptibility To Viral Infection Stat1tm1Dlv>/Stat1 B6.129-Stat1 11390995 Abnormal T Cell Activation Stat1fae>/Stat1 C57BL/6Apb-Stat1/Apb Increased IgG Level Stat1fae>/Stat1 C57BL/6Apb-Stat1/Apb Abnormal T-helper 2 Physiology Stat1fae>/Stat1 C57BL/6Apb-Stat1/Apb Increased Susceptibility To Viral Infection Stat1m1Btlr>/Stat1 C57BL/6J-Stat1 16688530 Abnormal Macrophage Physiology Stat1m1Btlr>/Stat1 C57BL/6J-Stat1 16688530 Altered Tumor Susceptibility Stat1tm1Rds>/Stat1 C3.129-Stat1 16618773 Increased Infarction Size Stat1tm1Rds>/Stat1 129S6/SvEv-Stat1/Tac 12223448 Decreased Apoptosis Stat1tm1Rds>/Stat1 129S6/SvEv-Stat1/Tac 17475277 Abnormal Redox Activity Stat1tm1Rds>/Stat1 129S6/SvEv-Stat1/Tac 17475277 Increased Cardiomyocyte Apoptosis Stat1tm1Rds>/Stat1 129S6/SvEv-Stat1/Tac 12223448 Abnormal Nitric Oxide Homeostasis Stat1tm1Rds>/Stat1 129S6/SvEv-Stat1/Tac 17475277 Increased NK T Cell Number Stat1tm1Rds>/Stat1 129S6/SvEv-Stat1/Tac 17475277 Decreased Susceptibility To Neuronal Excitotoxicity Stat1tm1Rds>/Stat1 129S6/SvEv-Stat1/Tac 17078933 Decreased Circulating Interferon-gamma Level Stat1tm1Rds>/Stat1 129S6/SvEv-Stat1/Tac 17475277 Abnormal Tibia Morphology Stat1tm1Rds>/Stat1 B6.129-Stat1 12923053 Increased Bone Mass Stat1tm1Rds>/Stat1 B6.129-Stat1 12923053 Abnormal Long Bone Morphology Stat1tm1Rds>/Stat1 B6.129-Stat1 12923053 Increased Osteoclast Cell Number Stat1tm1Rds>/Stat1 B6.129-Stat1 12923053 Increased Bone Resorption Stat1tm1Rds>/Stat1 B6.129-Stat1 12923053 Abnormal Osteoblast Differentiation Stat1tm1Rds>/Stat1 B6.129-Stat1 12923053 Increased Susceptibility To Viral Infection Stat1m2Btlr>/Stat1 C57BL/6J-Stat1 Impaired NK Cell Cytolysis Stat1m2Btlr>/Stat1 C57BL/6J-Stat1 Decreased Interferon-gamma Secretion Stat1m2Btlr>/Stat1 C57BL/6J-Stat1 Decreased NK Cell Degranulation Stat1m2Btlr>/Stat1 C57BL/6J-Stat1 Increased Susceptibility To Bacterial Infection Stat1tm1Dlv>/Stat1 involves: 129S/SvEv 14670297 Increased Susceptibility To Viral Infection Stat1tm1Dlv>/Stat1 involves: 129S/SvEv 14670297 Decreased Level Of Surface Class I Molecules Stat1tm1Dlv>/Stat1 involves: 129S/SvEv 14670297 Abnormal MHC II Cell Surface Expression On Macrophages Stat1tm1Dlv>/Stat1 involves: 129S/SvEv 14670297 Increased Circulating Interferon-gamma Level Stat1tm1Dlv>/Stat1 involves: 129S/SvEv 14670297 Decreased Susceptibility To Endotoxin Shock Stat1tm1Dlv>/Stat1 involves: 129S/SvEv 14670297 Increased Susceptibility To Bacterial Infection Stat1tm1Tdec>/Stat1 involves: 129P2/OlaHsd * BALB/c 14670297 Increased Susceptibility To Viral Infection Stat1tm1Tdec>/Stat1 involves: 129P2/OlaHsd * BALB/c 14670297 Abnormal Macrophage Physiology Stat1tm1Tdec>/Stat1 involves: 129P2/OlaHsd * BALB/c 14670297 Abnormal MHC II Cell Surface Expression On Macrophages Stat1tm1Tdec>/Stat1 involves: 129P2/OlaHsd * BALB/c 14670297 Decreased Susceptibility To Endotoxin Shock Stat1tm1Tdec>/Stat1 involves: 129P2/OlaHsd * BALB/c 14670297 Abnormal NK Cell Physiology Stat1tm1Dlv>/Stat1 B6.129S-Stat1 12370359 Impaired NK Cell Cytolysis Stat1tm1Dlv>/Stat1 B6.129S-Stat1 12370359 Increased Circulating Interferon-gamma Level Stat1tm1Dlv>/Stat1 B6.129S-Stat1 12370359 Increased Circulating Interleukin-12b Level Stat1tm1Dlv>/Stat1 B6.129S-Stat1 12370359