IRF8
Primary Info
Mutation
Mouse studies
DNA sequencing


External links Primary Information
MGI:96395
ENSMUSG00000041515		 Gene Symbol Irf8
Affected Anatomical Systems hematopoietic system phenotype,immune system phenotype,life span-post-weaning/aging,liver/biliary system phenotype,tumorigenesis
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id
MGI:3578920 Irf8myls Spontaneous myeloproliferative syndrome 14630819
MGI:1926332 Irf8tm1Hor Targeted (knock-out) targeted mutation 1, Ivan Horak 8861914
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id
Premature Death Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Enlarged Liver Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Increased Bone Marrow Cell Number Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Increased Granulocyte Number Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Increased Susceptibility To Viral Infection Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Lymphoma Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Increased Leukocyte Cell Number Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Enlarged Lymph Nodes Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Enlarged Spleen Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Spleen Hyperplasia Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Increased Immunoglobulin Level Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Abnormal Erythropoiesis Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Abnormal Megakaryocyte Morphology Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Decreased Lymphocyte Cell Number Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Increased Lymphocyte Cell Number Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Decreased B Cell Number Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Decreased T Cell Number Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Increased B Cell Number Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Abnormal Cytotoxic T Cell Physiology Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Increased Macrophage Cell Number Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Chronic Myelocytic Leukemia Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Abnormal Plasma Cell Number Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Increased Mature B Cell Number Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Increased Spleen Red Pulp Amount Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Decreased Interferon-gamma Secretion Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Increased Sensitivity To Induced Morbidity/mortality Irf8tm1Hor>/Irf8 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Premature Death Irf8tm1Hor>/Irf8<+ either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Abnormal Hematopoiesis Irf8tm1Hor>/Irf8<+ either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Chronic Myelocytic Leukemia Irf8tm1Hor>/Irf8<+ either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 8861914
Abnormal Myelopoiesis Irf8myls>/Irf8 involves: BALB/cJ * BXH2/TyJ-Icsbp1 15781580
Enlarged Spleen Irf8myls>/Irf8 involves: BALB/cJ * BXH2/TyJ-Icsbp1 15781580