mRNA IDs | Primary Information | |
NM_002163.2 | Gene Symbol | IRF8 |
Protein Name | interferon regulatory factor 8 | |
Alternate Names | H-ICSBP, ICSBP, ICSBP1, IRF-8 | |
Gene Locus | 16q24.1 |
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Disease name | Characteristic / Associated features | Category | inheritance type |
IRF8 deficiency | Susceptibility to Mycobacterial infections; oral candidiasis; cachexia; monocytopenia; disseminated BCG disease; severe immunodeficiency; impaired differentiation of mononuclear phagocytes; lack of dendritic cells | Congenital defects of Phagocyte number, function or both | Autosomal dominant |