Resource of Asian Primary Immunodeficiency Diseases

RAPID Original

CD81

External links	Primary Information
MGI:1096398 ENSMUSG00000037706	Gene Symbol	Cd81
	Affected Anatomical Systems	growth/size phenotype,hematopoietic system phenotype,immune system phenotype,respiratory system phenotype,skeleton phenotype
Allele Details
Allele ID Allele Symbol Allele Type Allele Name PubMed Id MGI:2180813 Cd81tm1Geha Targeted (knock-out) targeted mutation 1, Raif Geha 9380722 MGI:2180805 Cd81tm1Lvy Targeted (knock-out) targeted mutation 1, Shoshana Levy 9126932 MGI:2665072 Cd81tm1Tmiy Targeted (knock-out) targeted mutation 1, Toru Miyazaki 9250665
Phenotypic Details
Phenotypes Allelic Composition Genetic Background PubMed Id Abnormal Immune System Cell Morphology Cd81tm1Tmiy>/Cd81 involves: 129/Sv * C57BL/6 9250665 Abnormal B Cell Differentiation Cd81tm1Tmiy>/Cd81 involves: 129/Sv * C57BL/6 9250665 Abnormal Macrophage Physiology Cd81tm1Tmiy>/Cd81 involves: 129/Sv * C57BL/6 12796480 Decreased B Cell Proliferation Cd81tm1Tmiy>/Cd81 involves: 129/Sv * C57BL/6 9250665 Abnormal T Cell Proliferation Cd81tm1Tmiy>/Cd81 involves: 129/Sv * C57BL/6 9250665 Increased B Cell Proliferation Cd81tm1Tmiy>/Cd81 involves: 129/Sv * C57BL/6 9250665 Decreased B-1 B Cell Number Cd81tm1Tmiy>/Cd81 involves: 129/Sv * C57BL/6 9250665 Hypoactivity Cd81tm1Geha>/Cd81 involves: 129S4/SvJae * C57BL/6 11376857 Increased IgA Level Cd81tm1Geha>/Cd81 involves: 129S4/SvJae * C57BL/6 9380722 Increased IgM Level Cd81tm1Geha>/Cd81 involves: 129S4/SvJae * C57BL/6 9380722 Increased Dopamine Level Cd81tm1Geha>/Cd81 involves: 129S4/SvJae * C57BL/6 11376857 Increased B Cell Proliferation Cd81tm1Geha>/Cd81 involves: 129S4/SvJae * C57BL/6 9380722 Abnormal Nucleus Accumbens Morphology Cd81tm1Geha>/Cd81 involves: 129S4/SvJae * C57BL/6 11376857 Abnormal B Cell Morphology Cd81tm1Geha>/Cd81 involves: 129S4/SvJae * C57BL/6 9380722 Decreased B-1 B Cell Number Cd81tm1Geha>/Cd81 involves: 129S4/SvJae * C57BL/6 9380722 Decreased B-1a Cell Number Cd81tm1Geha>/Cd81 involves: 129S4/SvJae * C57BL/6 9380722 Increased IgG3 Level Cd81tm1Geha>/Cd81 involves: 129S4/SvJae * C57BL/6 9380722 Impaired Behavioral Response To Cocaine Cd81tm1Geha>/Cd81 involves: 129S4/SvJae * C57BL/6 11376857 Decreased IgG Level Cd81tm1Lvy>/Cd81 involves: 129S1/Sv * 129X1/SvJ 9126932 Decreased Susceptibility To Parasitic Infection Cd81tm1Lvy>/Cd81 involves: 129S1/Sv * 129X1/SvJ 12483205 Abnormal T-helper 2 Physiology Cd81tm1Lvy>/Cd81 involves: 129S1/Sv * 129X1/SvJ 9126932 Abnormal B Cell Morphology Cd81tm1Lvy>/Cd81 involves: 129S1/Sv * 129X1/SvJ 9126932 Decreased IgG1 Level Cd81tm1Lvy>/Cd81 involves: 129S1/Sv * 129X1/SvJ 9126932 Increased Brain Weight Cd81tm1Lvy>/Cd81 CByJ.129-Cd81 12357429 Thickened Cerebral Cortex Cd81tm1Lvy>/Cd81 CByJ.129-Cd81 12357429 Abnormal T-helper 2 Physiology Cd81tm1Lvy>/Cd81 CByJ.129-Cd81 9482907 Decreased Susceptibility To Type I Hypersensitivity Reaction Cd81tm1Lvy>/Cd81 CByJ.129-Cd81 9482907 Enlarged Hippocampus Cd81tm1Lvy>/Cd81 CByJ.129-Cd81 12357429 Abnormal CNS Glial Cell Morphology Cd81tm1Lvy>/Cd81 involves: 129S1/Sv * 129X1/SvJ * NIHS-BC 12357429 Increased Brain Weight Cd81tm1Lvy>/Cd81 involves: 129S1/Sv * 129X1/SvJ * NIHS-BC 12357429 Abnormal Astrocyte Morphology Cd81tm1Lvy>/Cd81 involves: 129S1/Sv * 129X1/SvJ * NIHS-BC 12357429 Abnormal Hippocampus Morphology Cd81tm1Lvy>/Cd81 involves: 129S1/Sv * 129X1/SvJ * NIHS-BC 12357429 Thickened Cerebral Cortex Cd81tm1Lvy>/Cd81 involves: 129S1/Sv * 129X1/SvJ * NIHS-BC 12357429 Abnormal Neuron Morphology Cd81tm1Lvy>/Cd81 involves: 129S1/Sv * 129X1/SvJ * NIHS-BC 12357429 Abnormal Hippocampus CA1 Region Morphology Cd81tm1Lvy>/Cd81 involves: 129S1/Sv * 129X1/SvJ * NIHS-BC 12357429 Enlarged Hippocampus Cd81tm1Lvy>/Cd81 involves: 129S1/Sv * 129X1/SvJ * NIHS-BC 12357429 Abnormal Hippocampus Pyramidal Cell Morphology Cd81tm1Lvy>/Cd81 involves: 129S1/Sv * 129X1/SvJ * NIHS-BC 12357429 Abnormal CNS Glial Cell Morphology Cd81tm1Lvy>/Cd81 either: (B6ByJ.129-Cd81 x CByJ.129-Cd81)F1 or (CByJ.129-Cd81 x B6ByJ.129-Cd81)F1 12357429 Increased Brain Weight Cd81tm1Lvy>/Cd81 either: (B6ByJ.129-Cd81 x CByJ.129-Cd81)F1 or (CByJ.129-Cd81 x B6ByJ.129-Cd81)F1 12357429 Abnormal Corpus Callosum Morphology Cd81tm1Lvy>/Cd81 either: (B6ByJ.129-Cd81 x CByJ.129-Cd81)F1 or (CByJ.129-Cd81 x B6ByJ.129-Cd81)F1 12357429 Abnormal Astrocyte Morphology Cd81tm1Lvy>/Cd81 either: (B6ByJ.129-Cd81 x CByJ.129-Cd81)F1 or (CByJ.129-Cd81 x B6ByJ.129-Cd81)F1 12357429 Abnormal Hippocampus Morphology Cd81tm1Lvy>/Cd81 either: (B6ByJ.129-Cd81 x CByJ.129-Cd81)F1 or (CByJ.129-Cd81 x B6ByJ.129-Cd81)F1 12357429 Thickened Cerebral Cortex Cd81tm1Lvy>/Cd81 either: (B6ByJ.129-Cd81 x CByJ.129-Cd81)F1 or (CByJ.129-Cd81 x B6ByJ.129-Cd81)F1 12357429 Abnormal Neuron Morphology Cd81tm1Lvy>/Cd81 either: (B6ByJ.129-Cd81 x CByJ.129-Cd81)F1 or (CByJ.129-Cd81 x B6ByJ.129-Cd81)F1 12357429 Abnormal Microglial Cell Morphology Cd81tm1Lvy>/Cd81 either: (B6ByJ.129-Cd81 x CByJ.129-Cd81)F1 or (CByJ.129-Cd81 x B6ByJ.129-Cd81)F1 12357429 Abnormal Hippocampus CA1 Region Morphology Cd81tm1Lvy>/Cd81 either: (B6ByJ.129-Cd81 x CByJ.129-Cd81)F1 or (CByJ.129-Cd81 x B6ByJ.129-Cd81)F1 12357429 Enlarged Hippocampus Cd81tm1Lvy>/Cd81 either: (B6ByJ.129-Cd81 x CByJ.129-Cd81)F1 or (CByJ.129-Cd81 x B6ByJ.129-Cd81)F1 12357429 Abnormal Hippocampus Pyramidal Cell Morphology Cd81tm1Lvy>/Cd81 either: (B6ByJ.129-Cd81 x CByJ.129-Cd81)F1 or (CByJ.129-Cd81 x B6ByJ.129-Cd81)F1 12357429